mRNA Cancer Vaccine Shows Promise; Sounding the Strep A Alarm; Phasing Out Tobacco Health news and commentary from around the Web gathered by MedPage Today staff Dec 13, 2022
Drug, Alcohol Deaths in Those Over 65; Medicare Advantage and Heart Attacks Also in TTHealthWatch: a new therapy for advanced melanoma Dec 10, 2022 podcast
Xeljanz Cancer Risks Detailed New paper provides full results from ORAL Surveillance trial Dec 07, 2022
Melanoma Resistant to Anti-PD-1 Responds to Tumor Infiltrating Lymphocytes Almost a third of patients had objective responses, which deepened over time, study showed Nov 16, 2022
Mixed Results With Fecal Transplant to Stimulate Cancer Immunotherapy Response Encouraging activity with antibiotic-free protocol but not with vancomycin preconditioning Nov 14, 2022
Terry Bradshaw's Merkel Cell Carcinoma After beating bladder cancer, the Hall of Fame quarterback was diagnosed with a rare skin tumor Nov 10, 2022
Immunotherapy First for BRAF Melanoma Edges Out Targeted Combination "Clinically meaningful" improvement in 2- and 3-year survival Sep 28, 2022
Neoadjuvant Anti-PD-1 Strategy Prevails Over Adjuvant in Resectable Melanoma Large increase in event-free survival with neoadjuvant plus adjuvant versus only adjuvant therapy Sep 13, 2022
Neoadjuvant Cemiplimab Active in Resectable Cutaneous Squamous Cell Carcinoma Pathologic complete responses seen in 63% of patients in phase II data Sep 12, 2022
Tumor Infiltrating Lymphocytes Reemerge as Potential Melanoma Option More than 50% increase in 6-month PFS versus ipilimumab after progression on first-line anti-PD-1 Sep 12, 2022
Keytruda Plus T-VEC Falls Short in Unresectable Melanoma No significant survival benefit with combination, but certain patients lived longer Sep 02, 2022
Make the Diagnosis: Don’t Lose Time Making This Diagnosis A 66-year-old woman presented to the doctor concerned after noticing a fleshy growth that had appeared on her left eye within the last few weeks. Aug 24, 2022
Sentinel Lymph Node Biopsy Can Be Therapeutic in Melanoma Patients 80% of patients avoided basin disease recurrence 10 years after a positive biopsy Aug 03, 2022
Are Skin Lesion Analyzers Ready for Prime Time? FDA panel not fully on board to reclassify computer-aided melanoma detection devices Jul 30, 2022
TKI Plus Immunotherapy Active in Melanoma After Anti-PD-1 Progression More than a fifth of patients responded to lenvatinib-pembrolizumab combination Jul 26, 2022
Number of U.S. Cancer Survivors Grows to 18 Million Most are over the age of 65, and disparities in care remain Jun 24, 2022
Something Fishy About Tuna and Melanoma Risk Higher total fish intake linked with 22% higher risk of malignant tumors Jun 09, 2022
Some Reassurance on Neurologic Effects of Checkpoint Inhibitors Other than headaches, neurologic adverse events fewer with ICIs than with chemotherapy Apr 22, 2022
Intratumoral Combo Shrinks Melanomas Refractory to Anti-PD-1 But response rate driven primarily by injected lesions, expert points out Apr 14, 2022
Dual Immunotherapy Improves PFS in Melanoma Resistant to Anti-PD-1 Six-month PFS rate more than doubled with nivolumab/ipilimumab versus ipilimumab alone Apr 13, 2022
Novel Fixed-Dose Immunotherapy Combo Wins FDA Approval Nivolumab plus relatlimab doubled progression-free survival in unresectable melanoma Mar 21, 2022
Mixed Message for Ultrasound in High-Risk Cutaneous Head and Neck Cancer Nodal metastasis detected more often than by clinical exam, worrisome false-positive rate Mar 18, 2022
Novel Therapies Active in Head and Neck Cancers High response rate with oncolytic virus plus immunotherapy in cutaneous lesions Feb 28, 2022
Merkel Cell Carcinoma Much More Likely to Recur vs Other Skin Cancers 5-year recurrence rate was 40% compared with 19% for melanoma Feb 23, 2022
Time's Up for Anti-PD-1/L1 Plus Targeted Therapy in BRAF Melanoma Third trial testing the approach shows no significant PFS improvement Jan 26, 2022
Active Surveillance for Melanoma Meets Reality of Loss to Follow-Up More than a third of patients lost to follow-up in "real-world" experience Jan 10, 2022
Melanoma Patient on Immunotherapy Develops Severe Dermatitis Clinicians faced with presumed dermatologic AEs urged to consider all differentials Jan 10, 2022
South Africa's Four COVID Waves; A New Prostate Cancer Treatment Combo Also in TTHealthWatch: anticoagulants and respiratory infections, and treating advanced melanoma Jan 08, 2022 podcast
Long-Term Data Reinforce Standard of Care in Unresectable Melanoma Landmark trial shows median OS of 72.1 months with nivolumab-ipilimumab Dec 01, 2021
Immunotherapy Combo Produces Durable Responses in Melanoma Brain Metastases More than half of patients responded to nivolumab-ipilimumab, 72% alive at 3 years Nov 18, 2021
Does Immunotherapy Late in the Day Affect Survival in Melanoma? Better outcomes when at least 80% of infusions were given earlier in the day, study found Nov 17, 2021
Immunotherapy First Wins in Advanced BRAF-Positive Melanoma DREAMseq shows 20% absolute improvement in 2-year survival with nivolumab-ipilimumab upfront Nov 15, 2021
Make the Diagnosis: Did His Helmet Cause It? A 28-year-old male Naval aviator asked his doctor about a number of papules and pustules that slowly appeared on his occipital scalp over the past few months. Oct 26, 2021
Case: VEGFR Inhibition in Merkel Cell Carcinoma Patient Disease stabilized after post-chemotherapy progression of the aggressive neuroendocrine cancer Oct 11, 2021
FDA Issues Orders Clarifying Rules for Marketing Sunscreens But more studies on sunscreen chemicals are still needed, advocacy group says Sep 24, 2021
Make the Diagnosis: But Will It Spread? A 45-year-old woman went to the doctor after noticing a rash that developed over a few weeks after the summer temperatures rose. Sep 23, 2021
In RA, Little Risk for Recurrent Cancer With Biologic Treatment Results important because most trials excluded patients with previous cancer, researchers note Sep 23, 2021
Adjuvant Pembrolizumab Boosts Recurrence-Free Survival in High-Risk Melanoma Also, fewer cases of distant recurrences in KEYNOTE-716 trial Sep 19, 2021
What's Causing Cancer Patient's Joint Pain While on Checkpoint Inhibitor? Here is how clinicians diagnosed this rare inflammatory side effect Aug 30, 2021
Rheumatic Events With Checkpoint Inhibitors: Tumor Type Matters Immune-related rheumatic adverse events most commonly seen with melanoma and GU cancers Aug 19, 2021
