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Tuberculosis

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A photo of the INOmax DSIR® Plus Delivery System for delivering nitric oxide gas in a hospital

Nitric Oxide, BCG, and COVID-19's Weakness

Clinical trials might reveal a common link

A photo of the BCG vaccine and dilutant with a syringe

BCG Vax: A Shot Against Lung Cancer in Native Populations?

60-year follow-up data from a vaccine trial found surprising results

Report: TB Could Be Conquered by 2045

It's within the world's means to end ancient scourge

Morning Break: Bankruptcy for Purdue? Burning Vape Rash; FDA Makeup Warning

Health news and commentary from around the Web gathered by the MedPage Today staff

Morning Break: Birth Control Regs Blocked; Hospital $ 'Fiasco'; Ginsburg Still Out

Health news and commentary from around the Web gathered by the MedPage Today staff

DNA Sequencing Holds Promise for Pinpointing TB Drug Susceptibility

Genotypic prediction had high sensitivity, specificity for first-line TB tx

Subunit Vaccine Against TB Shows Promising Results in Phase IIb Trial

Proof-of-principle study found vaccine efficacy of 54.0%

WHO: Global TB Deaths Down, But More Work Needed

Upcoming UN meeting on TB to address gaps in funding, treatment access

Ebola Vax in Pregnancy; Crowdsourced HIV Tests; Mystery Antimicrobial Licensing

News and commentary from the world of infectious diseases

Short-Course Tx Feasible for Preventing Active TB

Four months of rifampin non-inferior to standard 9-month isoniazid regimen

ID Break: Trained Rats Detect TB; E. Coli at Panera? Emricasan Flops in Trial

News and commentary from the world of infectious diseases

Dolutegravir Effective in TB-HIV Co-infected Patients

As integrase inhibitor regimen is rolled out, fears of drug-drug interactions lessened

Investigation Raises Concerns About Animal Study Misreporting

TB vaccine debacle traced to cherry-picked results from preclinical models

What Does Chopin's Pickled Heart Reveal? (LiveScience)

Composer died of pericarditis caused by tuberculosis

Hepatitis A Outbreak to Greet IDWeek

Homeless bear brunt of disease; delegates at low risk

Morning Break: Antibiotics Running Out; Teen Sex Interest Drops; Children Drive to OR

Health news and commentary from around the Web gathered by the MedPage Today staff

CDC: Organ Donor TB Case Reveals Flaws in Transplant Screening

Genotyping critical in outbreak investigation

DOT Cuts Death During Multidrug Resistant TB Treatment

U.S. data analysis shows 77% reduction with directly observed therapy

Asthma Biologic, Rally Among ATS Highlights

Attendees to organize on Capitol Hill; will also hear benralizumab phase III results

HIV Pioneer Mark Wainberg Dies

Passion for justice made him a leading figure

WHO: What About TB? (STAT)

Global priority list of resistant bacteria failed to include Mycobacterium tuberculosis

Many Smokers With Chronic Conditions Take Up E-Cigarettes

Sick smokers may be vaping to kick the smoking habit

Make the Diagnosis: An Excavator's Emergency

Case Findings: A 52-year-old African American man went to urgent care 2 weeks after returning home from a visit to an archaeological site in Utah. He complained of pneumonia-like symptoms including pleuritic chest pain, a dry cough, fever, arthralgia, and myalgia. However, when he developed a rash of smooth plaques he grew concerned it was more serious. Can you diagnose the patient?

Make the Diagnosis: Flu Symptom Surprise

Case Findings: A 26-year-old man went to his primary care physician with a sudden onset of flu-like symptoms including fever, chills, muscle aches, pleuritic chest pain, and a dry cough. He remarked that he felt terrible, but at least he had been healthy 2 weeks ago, when he and his girlfriend were vacationing in Costa Rica. He pulled out his phone and started sharing pictures of their spelunking trip - stalactites, stalagmites, and bats. What is your diagnosis?

Expand Screening for Latent TB: USPSTF

Task force argues benefit would be at least moderate and could be substantial

Make the Diagnosis: Military Service Mystery

Case Findings: A 21-year-old male Marine sniper returns from his fourth tour in Afghanistan with complaints of fatigue. He waited a month to seek medical attention because he believed he was simply tired from his last tour, but he has had trouble sleeping since he arrived home. Rather than dismissing his complaints as symptoms of PTSD, an alert clinician orders some blood work. The following is seen on a peripheral blood smear. What is the diagnosis?

Smells Like Tuberculosis?

Sensor study suggests breath samples might reveal disease

New Payment Model for Joint Replacement Faces Opposition

Musculoskeletal specialists and hospital administrators request delays, changes

ESC: Mixed Results with Steroids in TB Pericarditis

BARCELONA -- Adding steroids to anti-tuberculosis treatment for patients with tuberculous pericarditis can reduce the risk of complication and the resulting hospital admission, but adding prednisolone to tuberculosis treatment did not reduce the risk of death, researchers said here.

Three-Drug Cocktail Has Promise in TB

MELBOURNE, Australia -- An experimental, three-drug tuberculosis treatment regimen demonstrated bactericidal activity in patients with drug-sensitive or multidrug-resistant disease, researchers reported here.

Tweet of the Week: UNICEF's Viral 'Poo to the Loo'

Welcome to another edition of the MedPage Today Tweet of the Week! Every Friday, the editorial team highlights its favorite 140-character contribution from the healthcare twittersphere.

'Nose Knows' Devices Not Ready for Clinic

BARCELONA -- Within a decade, doctors may be able to diagnose cancer, asthma, and tuberculosis simply by having an electronic nose analyze a person's breath, researchers reported here.

Clinical Notes: FDA Turns Up Heat on Compounders

FDA inspectors found all but one of 29 compounding pharmacies making sterile products to be violating federal standards. Also this week: NICUs urged to be serious about B. cereus.

Sirturo Approved for MDR-TB

SILVER SPRING, Md. -- The FDA has approved bedaquiline (Sirturo) for treatment of multidrug-resistant tuberculosis as part of combination therapy, the agency announced.

TB No Barrier to Anti-TNF Treatment

WASHINGTON -- Patients being treated with tumor necrosis factor inhibitors who develop tuberculosis may safely reinstitute their biologic before completing the lengthy TB treatment regimen, a retrospective study suggested.

Persistent Pus in Ear May Signal Unusual TB

SAN DIEGO -- Ear involvement is a rare, but potentially devastating, manifestation of tuberculosis, as was shown in a case report presented here.

TB Outbreak Linked to Growth in Crack Cocaine Use

Sometimes traditional epidemiologic techniques are not enough to get to the bottom of an infectious disease outbreak, as illustrated by a rash of tuberculosis cases in British Columbia from 2006 through 2008.

False-Positive TB Skin Tests Prevalent in U.S. Army

BETHESDA, Md. -- Clusters of positive tests for latent tuberculosis infection in the U.S. Army appear to reflect a high number of false-positive readings from a more than century-old skin test, researchers found.