These investigators explored associations among early-life and in utero infections and cytomegalovirus-positive acute lymphoblastic leukemia in children, with signs pointing to underlying immune dysfunction.
Building on the conclusions of prior studies, a new analysis further explores the association between congenital cytomegalovirus infection and acute lymphoblastic leukemia in children.
This retrospective cohort study of Swedish national databases showed that, while it has been decreasing over time, the mortality rate of children with acute lymphoblastic leukemia was 40 times higher than that of the general population.
In GMALL trials 06/99 and 07/03, HCT performed with MUD cells was as safe and effective as HCT using MSD cells in this patient population, with a 5-year survival rate of approximately 58% in both groups. Prior studies on this topic were inconclusive.
In a case-control study that assessed the quality of life of adult survivors of childhood acute lymphoblastic leukemia, survivors reported higher quality of life than controls in psychosocial functioning and did not report worse outcomes in physical functioning.